Sample Preparation Techniques
Depending on your question and sample we offer a variety of different preparation techniques to ensure optimal preservation of your specimen:
- Preparation for scanning electron microscopy to study surface structures
- Negative Staining for rapid visualization of macromolecules, proteins, viruses, organelles or bacteria.
- Conventional chemical fixation for tissue samples and cell monolayers.
- High pressure freezing and freeze substitution for superior cellular preservation of cells and tissues.
- Rotary Shadowing for high contrast examination of protein complexes.
- Freeze fracturing and etching for visualization of surfaces, membranes and the inside of membranous compartment.
- Immersion freezing (“cryo plunge freezing”) for best possible preservation of small samples close to their native state.
- Tokuyasu as a method for cryo-sectioning in combination with immunogold labeling.
- Immunolabeling to locate structures of interest.
- Ultramicrotomy: ultra-thin sectioning of resin embedded samples.